The diagnosis of genetic conditions leads to the identification of at-risk family members. However, communicating genetic conditions can be abstract and difficult to comprehend. Therefore, it is important that those who were diagnosed with genetic conditions need to be supported and encouraged to communicate their conditions to their family. The objective of the study is to summarize and examine the effects of complex interventions to increase the communication of genetic conditions to their family members. In searching for relevant studies, various bibliographic databases and Cochrane Library were used. Hand search and additional electronic searches were conducted from 1 January 2000 to 5 March 2017. Data extraction was based on the PRISMA recommendation. Included studies were critically appraised using evidence-based tools and systematically synthesized. Lastly, meta-analysis and sub-analysis were performed. The seven studies included in this review used a complex intervention to increase communication of those diagnosed with genetic conditions. The meta-analysis's overall result (ORs=1.468, 95% CI=1.173-1.837, p<0.001) was statistically significant. This study provided evidence regarding the complex intervention's effectiveness to encourage those diagnosed with a genetic condition to communicate this information to their family members or at-risk relatives.