The first successful nephrectomy was performed by the German surgeon Gustav Simon on August 2, 1869 in Heidelberg. There are various indications for this procedure, such as renal cell carcinoma, a non-functioning kidney (which may cause high blood pressure) and a congenitally small kidney. Study period was between June 2014 and March 2018. Total nephrectomies done during this period were 146. Nephrectomies constituted 0.94 % of all the specimens received. Among them 94 were males and 52 were females constituting 64.4 % males and 35.6 % females respectively. In this study, among the 146 nephrectomies, majority was non-neoplastic lesions (114 cases) and 32 cases were neoplastic lesions. Among the 19 cases of renal cell carcinoma, majority cases were of clear cell pattern (8 cases), clear cell with papillary pattern, clear cells with anaplastic areas, chromophil type and chromophobe type, renal cell carcinoma –sarcomatoid variant. Occurrence of various pathological conditions such as infective, inflammatory and neoplastic lesions is common and incidental. Early diagnosis and treatment of the infective and inflammatory conditions will save the kidneys. In case of neoplastic lesions early identification of clinical features and proper usage of various diagnostic modalities will limit the Nephrectomies.