Background: There is a lack of studies on workplace safety in Africa and in particular as a Democratic Republic of Congo (DRC). The present study was designed to explore perceptions of the workers of the textile in DRC. The aim was to analyze how different risk perceptions can influence the behavior of security and health related to work. Methods: A cross-sectional study was conducted on a representative sample of textile Workers Company in DRC. Data collection (N= 228 subjects) was performed using a self-administered questionnaire. The survey questionnaire was developed using validated questionnaire for the assessment of work safety scale, the model of work organization and safety and performance behavior, supplemented by the European working conditions surveys. The internal consistency coefficients (Alpha de Cronbach) for reliability analysis were calculated separately for each measurement. Only scales with reliable internal consistency (Cronbach alpha index >= to 70) were selected in our analyses. The relationship between perceptions and work-related accident was analyzed by an ANOVA-one-way analysis for independent samples. For each scale, a correlation of Spearman was calculated. A logistic regression model was used to assess the association between the accident and the predisposing factors for the different scales of the questionnaire. Results: The correlations in this study are highly significant for different scales. The strongest correlations are between the perceptions of the Management Safety Practice and Supervisor Safety. The results showed a difference in the frequency of accidents according to workers' safety perceptions. Workers who were not victims of an accident presented higher mean scores for Job safety, Management safety practice, Safety knowledge and SCRD. The study shows that the accident rate is significantly related to Job safety (OR= 2,1), to Management safety practice (OR=2,9). Safety knowledge (OR=0, 37) and the SCRD (OR=0, 30) have protective effect. Conclusion: The present study shows that the perception of workers influences their health-safety behaviours at work. It’s highlighted the influence of occupational safety knowledge, the management system on the occurrence of the work accident. The results provide valuable guidance for policy makers, researchers and practitioners to identify mechanisms to improve workplace health and safety.