Objectives: To explore whether work-related value influence nurses job satisfaction among Saudi Nurses at Major Tertiary Hospital. Methods: Used a descriptive correlational research design was used. The study was conducted in all in-patient and Outpatient, and critical care units at the tertiary hospital. A convenience Sampling Technique was used. Data were collected through a self-reported questionnaire comprising demographic characteristics, a work value questionnaire, and a job satisfaction survey. Frequency, Percentage, Mean, Standard Deviation, and Pearson Product Moment Correlational Coefficient were used as the statistical tools in treating the data gathered. Results: One hundred thirty Saudi nurses participated; most of them were females working in the tertiary hospital. Respondents are working for more than five years in the hospital. Moreover, Saudi nurses are highly educated, more than 40 % are holding with a BSc, and most nurses at tertiary hospital in Riyadh have stayed in their current position. Results revealed that the respondents moderately agreed with the work values as perceived by Saudi Nurses and were slightly satisfied concerning their job satisfaction. A positive association between work values and nurses' job satisfaction is significantly related to work values and job satisfaction. Conclusions: The work value was positively associated with nurses' job satisfaction. Leaders should pay more attention to create positive work value to increase job satisfaction for nurses and increase their stay.