This study was conducted to analyze the profitability of Aman rice Binadhan-17 producing farmers in Sunamganj, Rangpur, Gopalganj, Pabna and Magura districts of Bangladesh. This study was based on primary data which were collected from 200 Binadhan-17 producing farmers. In the sampled areas data were collected through pre-designed interview schedule from November-December, 2019 for achieving the purpose. In the study, costs and return analysis were done on both cash cost and full cost basis for estimating profitability. The cultivation of Binadhan-17 was profitable from the viewpoint of the farmers. The study found that Binadhan-17 production is profitable. The average net return per hectare was Tk. 34207.56. The net return was highest in Rangpur (Tk. 38536.88/ha) followed by Magura (Tk. 36091.84/ha), Gopalganj (Tk. 35783.18/ha), Pabna (Tk. 32345.11/ha) and Sunamganj (Tk. 28280.80/ha) respectively. Benefit cost ratio was 1.47 and 2.17 on full cost and cash cost basis implying that the Binadhan-17 cultivation at farm level was profitable. Cobb-Douglas production function was chosen to determine the factor affecting gross return of Binadhan-17 production. All of the factors namely, human labour cost, power tiller cost, seed cost, fertilizer cost and insecticides cost were statistically significant and positive. The regression coefficients of irrigation cost for Binadhan-17 under all areas were positive but not significant. The farmers in the study areas encountered some constraints to Binadhan-17 production. The first ranked constraint was unavailability of seeds in all areas (84%). Other constraints were lack of training (64%), lack of technical know-how (38%), lack of capital (30%), lack of storage facility (17%), natural calamities (14%) and low education level of farmers (10%). The economic return of Binadhan-17 production encouraging to the farmer’s for more cultivation.