Diabetes Mellitus type 2 is said to be one of the complex diseases which is caused by complex interplay between genetic, epigenetic and environmental factors, while the major environmental factors, i.e., diet and physical activity level are well known, but the challenge is to identify the genetic factors involves in it. NGS (next generation sequencing) and GWAS (Genome Wide association studies) have led to technical development of genetic variants risked and protection of Type 2 Diabetes Mellitus. NGS which shows the amount of gene which has been expressed and there arrangement of nucleotide bases in the gene fragment which code for protein, also some genes , or a copy of gene which has lost the ability to produce a functional protein, may be due to mutation or inaccurate duplication in the sequence which are termed as Pseudo gene. These expressions of pseudo gene can occur due to SNP’s (Single Nucleotide Polymorphism) are DNA sequence variant that occur when a single nucleotide (A, T, C or G) in the genome sequence altered.