This descriptive cross-sectional design study aimed to assess the awareness level of nurses regarding the management of stroke patients in Rajshahi Medical College Hospital. A simple random sampling technique selected the 296 senior staff nurses who met the inclusion criteria. The study period was January 2018 to July 2018. The instruments consisted of the demographic questionnaire and awareness level of nurses regarding the management of stroke questionnaire. The researcher developed all questionnaires from the literature reviews. This study result indicated that the mean age of the subjects was 30.1, with an SD of 8.9. Their age range was 21-56 years. Most of the subjects, 232 (78.4%) was female and fewer males 64 (21.6%). Principles of management of stroke management include airway, breathing and circulation management (ABC management), specified by most 290 (98.0%) of the respondents. An equal portion of the respondent mentioned semi-prone position 264 (89.2%) and fluid management 264 (89.2%). The awareness level of nurses regarding the management of stroke revealed that (63%) of the respondents had satisfactory levels (20%) excellent and (17%) had low awareness regarding management of stroke. It had been seen that nurses did not answer some part of the questions, in which they needed reinforcement. This could be done by engaging them in continuous learning through the various approach to the training program. This finding suggests that the nurse's awareness need to be increased up to the highest possible mark to ensure safe and quality health care services regarding stroke management.