Different types of microbes playing important role in soil fertility, increase the food production both agricultural and economical point of view. Plant activities such as phytoremediation efficiency in the form root symbiosis formation by assisting the removal the toxic metals for the formation of rhizosphere. Once the pathogen enters into the plants through different routes, different immune responses elicited as plants show a variety of immunological behavior as a result of microbial attack. Plant growth-promoting rhizobacteria most commonly beneficial for promoting the plant growth as a result of nutrients uptake by plant and readily available to the nodule formations. Many of the green algae also involved in making the beneficial relationship to the microbes. These are blue-green algae and a host of other beneficial microorganisms. Fungi also show the symbiotic association with different plants mostly in hyphae formation. For example, the chitin-derived lipo-chitooligosaccharides. Transferring the some characters from plants and microbes to the different organisms helpful to establish the relationship among various food chain animals.