HIV-related cutaneous manifestations are very common and can be easily detected. If studied systematically, they can serve as diagnostic and prognostic markers. It is aimed to study the skin biopsies of various dermatological manifestations that occur in HIV seropositive patients attended to a tertiary care centre. This is a prospective study of cases of 104 were studied histopathologically who were Seropositive for HIV. Majority are of 31- 40 years (32.69%), and closely followed by the age group 21-30 years (28.84 %). Patients of both sexes were affected with males females ratio of 1.19:1. The most common cutaneous manifestation observed was Papulosquamous lesions with 37.5% cases and in this 53.84% cases were pruritic papular urticaria. Infections observed were 25%, among which majority were of bacterial infections. Drug reactions were observed in 15.3% of cases and majority of patients presented with Stevens Johnson syndrome. Dermatitis was seen in 11.53% of patients and seborrheic dermatitis is the common non-infectious dermatosis. Other cutaneous manifestations like vascular involvement, neoplasms contributed minority of cases. Most of the patients presented with cutaneous manifestations having CD4 count in the range of 350-500. It was conclude that the dermatological lesions are extremely common and may present with early, severe, unusual and atypical manifestations in the course of HIV infection. Awareness of the varied pattern of these manifestations would help in the early diagnosis and management of HIV infection, which would in turn decrease the morbidity and improve the quality of life of HIV-infected patients.