Background: When it concerns to lumbar spine surgery, patients have the option of either general or regional anesthetic. General anesthesia is the most often used anesthetic method (GA). These patients had spinal anesthesia (SA) and general anesthesia (GA) to see which had better intraoperative and postoperative results. Methods: Multicenter non-randomized quasi-experimental prospective study has been conducted in Rajshahi Medical College Hospital and tertiary care Hospital Rajshahi, Bangladesh. From June 2019 until December 2020. The research involved a total of 72 patients. There were 37 patients in the GA Group and 35 in the SA Group who were randomly assigned to the two groups. They also kept track of the patient's heart rate, systolic and diastolic blood pressure, blood loss, satisfaction with the operating circumstances, and the intensity of postoperative discomfort assessed using a visual analogue scale (VAS). Results: This study found that the SA group suffered from considerably less blood loss than the GA group. The SA Group saw substantially less changes in intraoperative maximal blood pressure and heart rate (p=0.05). This group was substantially satisfied with their surgeons' work (p=0.05). There were substantially fewer patients in the SA group who required postoperative analgesics and postoperative mean VAS than in the GA group. (p < 0.05 for both). Conclusions: While maintaining improved perioperative hemodynamic stability without increasing undesirable side effects, our research demonstrated that SA was superior to GA in delivering surgical analgesia and reducing blood loss.