It is a well known fact that the urinary stone crystal disease affects a considerable number of people and makes it a major socio-economic problem in the world. Several environmental factors influence the formation and growth of many crystalline materials in the biological fluids in a human urinary system. As in vivo experimentations have limitations, in vitro investigations have been made by several researchers in the past. A success in finding the environmental factors promoting or inhibiting the formation and growth of urinary stone crystals will be of immense help to the mankind. This article provides a bief account of the results obtained in this regard along with providing some information on urolithiasis and gel methods for crystal growth. The focus is made on Whewellite, Brushite and Struvite crystals as these are among the dominant and well studied ones.