Qillat-i-Darqiyyat (Hypothyroidism) is one of the most common disease conditions under endocrine system, occurring in 5% of individuals. A 19 years old female patient, approached the Outpatient department of NRIUMSD, Hyderabad, with complaints of weight gain, loss of hair, poor appetite, and general weakness and was treated with Unani medicines i.e., Asgand (Withania somnifera) and Brahmi (Bacopa monnieri) for 8 weeks. All the basic blood and urine investigations were done before and after the treatment along with the thyroid profile test. After 8 weeks of treatment, the patient showed significant relief in symptoms as assessed by a decrease in Zulewski's clinical score which was 7/12 point before treatment and 4/12 points after treatment, and a decline in TSH level from 6.73 µ IU/mL to 2.53 µ IU/mL. Although, the serum T3 and T4 levels remained within normal range during the course of treatment. Thus, this study is suggesting that Unani medicine can be used effectively in the management of Hypothyroidism.