Aims and objectives of the study: The objective of this in vitro study aimed at evaluation with comparision of extrusion of the debris apically using Reciproc, WaveOne with OneShape, Protaper Next rotary file systems. Materials and Method: Sixty mandibular premolars with single root and singe canal were selected. The samples were distributed along four similar groups based on the length between cementoenamel junction and the apex. To collect the extruded debris glass vials with rubber stoppers were used. Pre weighed glass vials were used to collect the debris extruded and the irrigant. Preparation sequences were divided as follows: Group 1: A R25 Reciproc. Group 2: The WaveOne Primary file. Group 3: A classic OneShape file. Group 4: Multiple files ProTaper Next system. Once the instrumentation was completed with respective groups and files, tooth was remoed from the glass vial and root surface was rinsed with 1ml of bidistilled water into the receptor tube.within to make sure the debris accumulated is in the glass vial completely. Preweighed glass vials containing the debris was weighed in an electronic balance with an accuracy of +/- 0.00001g. Results: Readings, data collected, analyzed, computerized with the help of SPSS (STATISTICAL PACKAGE FOR SOCIAL SCIENCES software), 20.0 VERSION. One-way Analysis of Variance (ANOVA) and Tukey HSD test statistical analysis was done. All instruments resulted in extrusion of debris and irrigants, but highest average extrusion of debris was eident in Reciprocting file systems.Conclusion: Among the four different file systems used, Reciproc file system showed the maximum apical extrusion.