Background: Chronic renal failure (CRF) patients with superseded diabetes are immune-compromised and are prone for oral candidal infection. Aim: To study the Antifungal drug susceptibility of oral candida species isolates in chronic renal failure patients with type 2 diabetes. Material And Methods: A total of 98 individuals including 73 cases of chronic renal failure with type 2 diabetes mellitus and 25 healthy individuals as controls. The diabetic patients were divided into 3 groups according to their glycemic index; 22 controlled diabetes (HbA1c ≤5%), 27 moderately controlled (HbA1c 5-7%) and 24 Uncontrolled diabetes (HbA1c ≥7%). Salivary samples were collected in as sterile container with phosphate buffered saline and then immediately transported to various mycological investigations and antifungal susceptibility tests. Results: There was significant difference in incidence of candida species in uncontrolled diabetes when compared to moderately controlled, controlled and normal patients (P<0.05).The higher number of colony count was seen among uncontrolled and moderately controlled diabetes than controlled and healthy subjects. Candida albicans is the most prominent species among the groups. C. albicans showed increased resistance to Amphotericin B and fluconazole in diabetic patients in comparison to control group. Other species showed variable sensitivity patterns. Conclusion: An accurate identification of oral candida species and their drug susceptibility, in chronic renal failure with type 2 diabetes patients mandates proper treatment to avoid recurrence and drug resistance.