Aims and Objectives: The aim of the study was to evaluate the prevalence of awareness among dental interns regarding endodontic flare ups and its management. This cross-sectional survey was targeting the 2017-2018 patch of dental interns in all the dental colleges around the western region of Saudi Arabia which include: Ibn Sina national college, King Abdulaziz University, Al-Farabi and Al-Bateerjee colleges in Jeddah, also Um Al Qura University in Makah and Taibah University in Al Madina. Methods: A total of 294 participants in this cross-sectional survey divided into two parts 16 closed-ended questions in which first part of the questionnaire assessed the demographic profile of the Interns such as age, gender, and the Institution they belong to. The second part consisted of 12 multiple-choice questions to investigate their knowledge and awareness about endodontic flare up and its management. The study targeting the 2017-2018 patch of dental interns in all the dental colleges around the western region of Saudi Arabia. Relationship between these factors and are‐ups was examined. Statistical analysis was done using Pearson Chi-square test and Fisher’s exact test. Results: majority of the students having the higher incidence of flare-ups with Necrotic pulp [52%] while [41.5%] student participants, the best choice of treatment for cases of severe inter-appointment pain is re-instrumentation, occlusal reduction, antibiotics, and analgesics. Conclusions: Flare-ups develops due to many factors, which are directly interdependent and interrelated. Incorrectly measured working length of the root canal is a mechanical factor causing the damaging effect of the chemical and microbial factors to the apical periodontal tissue. Development of the flare-up after the endodontic treatment procedures is also influenced by demographics, general health, clinical symptoms, condition of the pulp and apical periodontal tissue, tooth being treated, number of visits during the treatment and intracanal medicaments. Women compared to men are more prone to are‐ups.