Introduction: In the modern world, there is a rising trend of diabetes mellitus and hypertension in developing countries like India, which is favouring a rise in complications like Chronic kidney disease.Thrombotic complications are a high possibility in chronic kidney disease (CKD). In recent days, abnormalities in platelet parameters are found to be an effective tool in risk stratification of CKD patients to develop venous thromboembolism and vascular disease. Our study was conducted to assess relation of platelets indices, platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) in CKD patients. Material and methods: A retrospective evaluation was conducted on the blood biochemical data and hematological data obtained from the records of patients diagnosed with chronic kidney disease for over 5 months (January 2021- May 2021) . The demographic data, urea, creatinine values and hematological findings were collected from the patient lab reports from the Department of Biochemistry and Pathology of Saveetha medical college and hospital. Platelet indices were obtained using Sysmex -XN 1000 automated analyser. 131 cases of known CKD was collected and correlated with Platelet indices values. Results: On gender and age distribution, male patients were predominant and age group between 41 to 60 were commonly affected. In CKD stage 2-39 patients, stage 3-32 patients, stage 4-28 patients, stage 5-14 patients were categorized according to their clinical findings and laboratory investigations. On correlation, there were no statistically significant differences in any PLT indices (platelet count, mean platelet volume, platelet distribution width and plateletcrit).However, Platelet count lower as the stage increases and MPV, PDW and plateletcrit were slightly higher in stage 5 CKD when compared with other stages of CKD. Conclusion: Platelet indices plays major mechanism in pathological processes of vascular thrombosis. The efficacies of platelet indices associated with CKD patients remain unknown. Prospective randomized controlled trials involving larger numbers of CKD patients are needed to determine the associations with platelet indices.