Leprosy is a skin disease affecting also the nerves was caused by Mycobacterium leprae. Multidrug therapy (MDT) cures the infection, but immunological reactions may occur and neuropathy may lead to disability and deformity. The current study aimed to understand the immune status of the patient before and after treatment by correlating histological subtype and peripheral blood lymphocyte count. Total number of 35 cases was studied. Blood samples were taken from the patients and complete blood picture was done before instituting the MDT including TLC and DLC. After 6 months of treatment, patients were followed up with complete blood picture. In lepromatous leprosy group (BL+LL) total mean WBC count was increased with 11,414 (range 7,000- 22,600 mm3) above the range of normal limits before treatment. It was in the mean normal range after treatment with 8514 (range 5,900- 11,000mm3). Lymphocyte count has increased after treatment. After the treatment, there is considerable increase in lymphocyte count. It was in the range of 34% to 42% with a mean value of 38.1%.