Heavy metals are included among leading global pollutants and they get bioaccumulated at different trophic levels of ecosystem and their concentration and associated risk to them of vast range harmful health side effects increases along with the rise of trophic level, not only in humans but also in other forms of life. But microbial remediation can play significant role in biodegradation of bioaccumulation of heavy metals. In this regard, either the addition of suitable microbial strains likes Pseudomonas, Staphylococcus, E. coli etc. in ecosystem or their transgenic forms have been found quite useful and further investigations are also required to facilitate not only to developed regions but also to developing global zones.