Newcastle disease is caused by paramyxo viruses, very infectious disease present in birds harms most. Clinical and electro-physiological findings in the patients of SMA revealed that the patients experience critical decline in the functions of motors with unit loss rapidly. Tumors of heart in dogs typically represents either non-functional chemodectoma or ectopic thyroid carcinomas which is also non-functional. Spontaneous-malignant-lymphoma present in sheep, through well known in tumor investigations in the slaughtering houses and in the diagnostic workshops. The hallmark clinical finding in cases of external caseous lymphadenitis is the development of abscesses in the region of peripheral lymph nodes. Anthrax is a disease which is usually spread by feeding and by the contaminated water with the spores and these spores can last in the soil for several years. Mostly the anthrax is cured easily in start stages and is easy way and control to further increase of this disease. Orf is the disease commonly present in sheep and goats throughout the world. It also known as scabby mouth or sore mouth. The outlook for Orf sickness, which is a zoonotic host switch infection, is not especially bad. There are different parasitic diseases of animals, coccidiosis is one of the parasitic disease of poultry and rabbits.