This article presents results of the study on 100 patients with pathology of gastrointestinal tract (erosive bulbitis, nonspecific ulcerative colitis, chronic gastritis, ulcer disease and gastric cancer) in order to investigate association of these pathologies with different genotypes of Helicobacter pylori in Uzbekistan. The researches showed, that the most frequent association with Cag+ was noted in the patients with ulcer disease and gastric cancer, and in a less degree with erosive bulbitis and nonspecific ulcerative colitis.