Objective: To evaluate the predictive values of urinary calcium creatinine ratio and microalbumin in pregnancy for detection of patients who are going to develop pre-eclampsia. Methods: Spot urine samples were taken in 150 asymptomatic pregnant women between 20-28 week of gestation to determine Urinary calcium creatinine ratio and micro-albuminuria in outpatient department of TRS, hospital. The statistics was analyzed using Chi square test and t test for determine the significant association of clinical findings of pre-eclampsia to CCR and micro-albuminuria. The predictive values of CCR equal to 0.04 or < 0.04 and microalbuminuria were determined by Area under Receiver Operator Curve (ROC) for pre-eclampsia. Results: The Calcium to creatinine Ratio found to be a good diagnostic test for prediction of pre-eclampsia with sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of 83%, 96%, 75%, and 98% respectively. The statistical accuracy of 95% and significant p value of <0.001. The microalbuminuria is came out to be fair diagnostic test to prediction of pre-eclampsia with sensitivity, specificity, PPV and NPV of 65%, 86%, 42% and 94% respectively. Conclusion: CCR to be recommended as a good screening test for prediction of preeclampsia at cut off value of 0.04 in spot urine sample of all pregnant women without any symptomatology while microalbuminuria is a fair test for same at present.