Papillary Lesions of Breast, defined histologically by presence of fibrovascular cores with varying epithelial proliferation, encompass a wide spectrum of benign intraductal papilloma, atypical papilloma with ADH/DCIS, papillary DCIS, encapsulated papillary carcinoma, solid papillary carcinoma and invasive papillary carcinoma. Due to tumor heterogeneity, sub-classification is diagnostically challenging on histopathology alone thus requiring help of immunohistochemistry (IHC). The aims & objectives of this study was to assess papillary lesions of breast and to determine the histopathological features which can categorize various papillary lesions along with IHC.A retrospective analysis of 39 cases of papillary breast lesions retrieved over a period of 8 years (July 2011 to July 2019) was done. The histopathology was reviewed independently by two pathologists using a standard review form which included 10 parameters. IHC was applied on all the cases to confirm or refute the histopathological diagnosis. Statistical analysis were performed using PRIMER software. Out of 39 cases, the most common papillary breast lesion was benign intraductal papilloma with 28 cases (72%), followed by one case of atypical papilloma with DCIS (2%) and 10(26%) malignant papillary lesions. The statistically significant histopathological features which aided in differentiating benign lesions from malignant lesions were presence of apocrine metaplasia, bland nuclear features and absence of atypia. IHC was necessary in diagnosing all the malignant papillary lesions and 2 benign papillary lesions. Papillary lesions of breast are difficult to interpret on microscopy alone due to intrinsic heterogeneity. The combination of histopathological features along with IHC helps in distinguishing benign, atypical and malignant papillary lesions.