Plurihormonal pituitary adenomas are rare tumors that present cellular immunoreactivity for more than one pituitary hormone. The most common form is that combining growth hormone and prolactin, but the combination of growth hormone with adrenocorticotropic hormone causing Acromegaly and Cushing's disease is extremely rare and clinical signs may be subtle. We have demonstrated the clinicopathological characteristics of plurihormonal pituitary adenomas through the case of our 25-year-old patient who had a pituitary macroadenoma with an initial clinical picture dominated by acromegaly and mild cushingoid features.