Cotton belongs family Malvaceae, genus hirsutum and tribe Gossypiae, and it is usually divided in to two types: the wild and the cultivated cotton. To understand the molecular base of the plant reactions to main abiotic stresses like salinity and drought is important for bio-technological applications of stresses adaptations for crop development. In this perspective, thousands of stress receptive genes are recognized and a small number of them are characterized functionally. Thrilling temperatures, salinity and the water reduction are major abiotic stresses which are reflected the primary issues, which reduces the cotton production. The global drop of cotton crop is fifty percent due to abiotic stresses or supreme cotton crop yield; they need optimal growth situations like the other field crops. Due to drought stress response, boll of cotton plant and its leaf area is reduced and any change in carbon uptake also put its impact on photosynthesis. Polyphenolic with capable contraceptive reactions, a gossypol and terpenoids with anti-inflammatory effects and cytotoxic activities of trans-caryophyllene are some examples of potential chemical compounds present in cotton with their valuable impacts on humans and animals health as well. . Cotton seeds are now inspected as most potential co-product and a high valuable part of cotton processing chain and it is most viewed left over by product of cotton.