Fungal infections have become more frequent, due to its extension population are at higher risk of utilization and treatment mode that permits long lasting survival of the patients. The histopathological detection of tissues shows fungal invasion of tissues and vessels along with host reaction with fungi and it could be a crucial tool for defining detection significance of positive culture isolates. However, there is very little illustration about morphological features of fungi, which are specific. The histopathologic detection should illustrate fungi and must include presence or absence of tissue invasiveness and host reaction with infection. Although, fungal species associated to genus Candida could result in acute vulvovaginal infection, Candida albicans are significantly more prevalent etiological agent mainly for severe chronic condition named recurrent vulvovaginal candidiasis (RVVC). The recent advancement in pathogenic process and host immune system response to C. albicans had also been seen. Vaginal Candidiasis is known to be one of the common gynecological problems found in females. As it had been seen that half of the women in their lifetime experience suffer from vulvovaginal candidiasis and few with recurrent candidiasis. Cervical and vaginal secretion is the defending tool from ascendant infection pathway spreading. The component that could disturb vaginal environment is endogenous, infectious and iatrogenic factors and is most common factor susceptible for vulvovaginal candidiasis (VVC).