Introduction: Purpose: The purpose of this paper is to share insights, research findings and discuss key issues related to workload factors and their influence on the wellbeing of ICU nurses working in a Saudi Arabian. Design/Methodology/approach: The authors used a mixed method approach and using a convergent parallel mixed methods design. A qualitative and quantitative approach was adopted for the study that sampled national and foreign nationals ICU nurses to explore the various workload factors that influenced their wellbeing within the ICU environment during direct patient care. Results: The findings from the study were aligned to the JDR Model and provided evidence that ICU nurses experienced various workload factors that influenced their wellbeing and productivity within the ICU environment. The research paper has provided a platform for ICU nurses to voice their concerns on workload influencing their wellbeing in the critical care environment and cry out for the need of support and wellbeing program for the organisation to overcome workload factors experienced. Research limitations/implications: The limitation that was faced by the researcher was the timeline for conducting the current research, which was governed by the University’s policies and protocol. Identified various workload factors and its influence on ICU nurses wellbeing guided the study findings to formulate a comprehensive managerial framework as a support for nurses specifically coping strategies for the organisation. This will assist nurses in all other sectors of the organisation to utilise such employee wellness programs in coping with workload factors influencing their wellbeing. Practical Implications: Healthcare organisation across the globe is challenged to achieve nurse workforce stability, safety, and well-being. It was evident that the participants experienced many workload challenges that influenced their wellbeing within the various ICUs. This study sets out the key messages for health care managers to empower and to meet the needs of ICU nurse related to health and well-being. The findings formed the foundation for management contribution to provide improved and seamless support to the health and well-being of ICU nurses. This approach is a guide to support the nurses and implement employee well-being programs to leverage off the work demands and stress within the health care sector. Originality/Value: This paper explores the various workload factors experienced by ICU nurses and its influence on their wellbeing in A Saudi Arabian Hospital from national and international perspectives. The authors were able to explore various workload factors from diverse population and multi-cultural backgrounds within the organisation. The value of the research will enable health care organisations locally and internationally to ensure that the organisation implements well-being programs as a support for nurses.