Purpose of the study: Modern economy cannot be thought without banks. The banks of Bangladesh have great contributions to the development of this country. This study concentrated on the commercial banks in Bangladesh to determine the effect of specific factors on financial performance. Design/methodology/approach: The study applies the statistical tools SPSS 20 version through descriptive statistics and a panel regression model which comprises 16 commercial banks listed by DSE and CSE yielding a total of 80 observations over the period of 2016-2020. Findings: The specific objectives of this research were obtained from the performance model indicated there is a significant positive correlation between Y1 of commercial banks with X1, X2, X3, X4, X5, and X6 while negative correlation X7 showed the statistically insignificant impact on performance. From the regression model reveal that X1 and X2 and others variables have statistically significant while X3, X4, X5, X6, and X7 had an insignificant impact. However, it is recommended that empirical studies should be undertaken in the same field to find out what more bank factors could affect the performance of banks. Applications of this study: This study has greater importance for government, bank managers, investors, academicians, and scholars etc. Originality/Novelty: In this study, the number of bank is taken as a different factor in selected commercial banks and bridges the gap in the banking literature of Bangladesh.