Tuberculosis (TB) is a communicable disease that is a major cause of ill health, one of the top 10 causes of death worldwide. Actually, TB is curable disease if the patients adhere and treatment be effective. This study aims to identify factors related to medication adherence among pulmonary TB patients. This study was a systematic literature review by identifying cross-sectional study, published in 2016-2021, in English and Indonesian, and full-text. The electronic database that used was Google Scholar and Science Direct with the keywords “Factors” “Medication” AND “Adherence” “TB Pulmonary”. The results obtained 10 articles that related to medication adherence among pulmonary TB patients. There were five dimensions of factors: therapeutic factors, health system factors, environmental factors, socioeconomic factors, and family support factors. Health workers need to consider these factors so that medication adherence among pulmonary TB patients will increase.