There are many viruses that cause different infectious diseases in human as well as in vertebrate systems of different animals. Coronaviruses are the most infectious viruses belonging to the family Coronaviridae. The genome of coronaviruses are made up of RNA and size about the ~30 kb that contain the 5′ cap structure along with a 3′ poly (A) tail. These are helpful for translating the different proteins causing infections such as replicase proteins. Different types of immune based responses evoked once the viral attack on the immune cells of the body. Accessory proteins also playing important role as inflammatory responses once viral attack on immune cells and release of different inflammatory genes that are involved in progression of COVID-19. One of such kind of response from interferon’s I and III are cytokines that playing important role against the viral infections. Lopinavir and Ritonavir both inhibiting the viral replication and translation by targeting the viral relapse and other necessary genes involved in viral genome. Dexamethasone, may help manage symptoms in people with COVID-19 by reducing inflammation. Vaccines and different therapeutics medicines are employed to damage the structure of virion and nucleocapsid by underlying the cellular mechanism of COVID-19.