In developing countries, the sexually transmitted infection is one of top five diseases to which adults seek for medical help. There is an association between common STIs and sexual transmission of HIV. Therefore, control of STIs receives attention to control the spread of HIV. A retrospective study was conducted in Teaching Hospital Batticaloa during the period between 2014 and 2016. A total of 1190 cases were newly registered in STD clinic, of which 317 cases were confirmed to be having STIs. A total of 317 confirmed cases of infection episodes were recorded in all patients attended to STD clinics during this three years. Of which, 96.8% were due to STI and 3.2% due to lower reproductive infections. Among the STIs; genital herpes (22.71; Syphilis (16.71%). gonorrhoea infection 4.41%. Trichomonas vaginalis was 7.25%. During the period of three years only one case of HIV was identified. Hepatitis B infection constitutes to 15.14% stays in order next to Syphilis .bacterial infections shows a decreasing trend while a gradual increase of viral infections is observed. Public health should be strengthened especially use of condom and avoiding sexual contact with unreliable sexual partner in order to control STIs