Gossypium hirsutum L. is most essential cash crop which provide fiber to fabric industries globally. Cotton is the world leading crop, is plenteous and produced economically, manufacturing products of cotton relatively cheap. The threads can be prepared in to a wide-ranging fabrics variety like light-weight laces and voiles to heavy-weight sailcloth’s and heavy piled velveteen’s, appropriate for large diversity of wearing apparel, furnishings and much industrial consumption. Fabrics from cotton can be tremendously long-lasting and resilient to scratch. Reduction of water loss through leaves is a crucial phenomenon in cotton plants under drought stress. ABA is one of the most important stress hormones and participates in various crucial physiological processes during the plant life cycle, including stress responses, development and reproduction. Exogenous application of osmo protectants and various plant growth regulators have been found effectively to enhance drought tolerance in cotton. To increase the tolerance in cotton against drought stress, transcription factors are excellent candidates for the plant scientists. Cotton is an important cash crop worldwide. Although it is classified as one of the most salt-tolerant major crops and considered a pioneer crop in reclamation of saline soils, its growth and development as well as yield and fiber quality are negatively affected by excessive salts in the soil.