Introduction: The annual number of infertility rate is increasing day by day, globally. The number of infertile couples is estimated at between 60 and 80 million. Objective: Our main aim was to identify the clinical profile of the patients with male infertility. Methodology: This descriptive cross sectional study was conducted in Care Hospital, Dhaka, Bangladesh during the period from January 2019 to December 2019. Study selected 200 male infertile patients from the record book as study participant. Result: The mean age was 36.14 ± 5. The highest no of patients 104 (52%) were in the 35 to 44 years’ age group. The main disturbance was Asthenozoospermia in 59 (29.5%) cases and Diabetes Mellitus11 (5.5%). Conclusion: The study reveals that Asthenozoospermia was the most frequent sperm alteration in male infertile patients. Moreover, patient’s age range from 35-44 years old was the most facing the problem of Infertility in Bangladesh.