This review is about the most prevalent disease Leishmaniasis at the various areas of Pakistan. This paper explains Leishmania as the cause of the disease, geographical distribution of its species, genome, morphology, vector specie, clinical forms, treatment, control and epidemiology of the Leishmania at various provinces and cities of Pakistan and its neighboring countries. The paper briefly concludes the main source of the prevalence of the disease and the precautionary measures that should be taken against Leishmaniasis