Coronaviruses as the most infectious group of viruses and their mode on action on respiratory tract and borne on other diseases are major risks for new disorders associated with the respiratory system. One of the biomarker in progression of pathogenesis of COVID-19 is the Granulocyte-macrophage colony-stimulatin (GM-CSF). This makers appears to more in high concentrations as compared to those normal cell. The major feature about the cellular mechanism of the COVID-19 is the changing shape of the strain that becomes difficult to control easily. Different symptoms and preventive measures are needed to exploit them. COVID-19 has influenced on the mental health by suppressing the different functions of neurons thus increasing the chances of brain disorders. Other neurological disorders symptoms are loss of smell in the form of anosmia, weakness, fatigue and a change in taste dyspepsia. ACE2 receptors are mainly involved in responses in case of entry of coronaviruses in the host cell. Airways have more ACE2 receptors than the rest of the respiratory tract. Nucleic acids vaccines are designed to target the spike proteins of the coronaviruses by inactivating of the antigen that can be injected into the cells of the human body. . There are many vaccines available for targeting the antigen behind the cellular responses to the nucleic acids. It implicate the immune responses once the vaccine injected into the body by producing the antibodies.