Zoonotic diseases are group of those diseases that transmitted from animals to the human in the form of germs categorized from microbial sources. Rabies is characterized by biting the dogs, cats and transmitted by infections from animal’s surfaces to the human body. Psittacosis is the zoonotic disease that is transmitted by bird’s infections that leads to abnormalities in liver functions. Brucellosis also the zoonotic disease characterized by infections particles in the form of food products. Polluted foods lead to food borne disease. Vaccines are used for the treatment of rabies in order to control the rate of transmission of rabies. The main purpose of vaccines is to develop the immunity against virus and provides long life protection against the microbial environments. Different antibiotics such as doxycycline and rifampin are used for Brucella but increasing the resistance against that drugs leads to challenge the mechanisms of resistance of antimicrobial drugs. There is need to synthesize the genome based drugs that can make certain alterations in genomics of the animals.