Background: -Ocular complications are common in diabetes and cataract becomes the major cause of blindness in diabetic patients. Objective: Oxidative stress was assessed by estimating lipid peroxidation product (LPO) in the form of MDA and non-enzymatic antioxidant vitamins C in the serum. Methodology: A number of 100 cases of diabetic cataract in the age group of 45-70 years, compared with 100 healthy controls. Results: Serum levels of MDA and Vitamin C between cataract cases and control groups were found to be statistically significant (P<0.0001). Conclusion: The present study revealed that low levels of antioxidants and increased oxidative stress may have a role to play in the etiopathogenesis of the diabetic cataract.