Infectious diseases are caused by transmission of infections from animals either in the form of biting of different tissues of human. Infectious diseases are also caused by organisms such as bacteria, viruses, fungi or parasites and transmission rate high such as rabies, tuberculosis, HIV/AIDS and Ebola viruses. Major histocompatibility complex (MHC) is involved in the immune responses against the pathogenic attack. Natural Killer T cells, lymphocytes, macrophages and interleukins are involved in immune responses. Cytokines releases that causes immune responses by releasing the chemicals. Bacterial infections are those caused by salmonella and E.coli are most common in modern environment. Fungal growth on skin causes different fungal infections that leads to borne of many skin diseases, such as ringworm and athlete's foot. Histoplasma capsulatum affects the lungs in two ways either in the form of acute or chronic inflammation. Tuberculosis (TB) is the most infectious disease widespread caused by Mycobacterium tuberculosis that causes lungs and respiratory problems. Different types of genes are involved in immune responses when there is attack of coronavirus to the specific immune cells. Genome editing helpful for editing the specific gene in the microbial cells that causes the inhibition of genes causing infectious diseases.