Botriomycome exceptionally reveals an infectious bone site. We report a case of botriomycoma revealing tuberculosis osteitis of the tibia in a 38-year-old man without particulars antecedents, who consulted for a cutaneous lesion at the 1/3 proximal of the left leg evolving over 4 months, with bone involvement in imaging, in whom the histological examination of the cutaneous and bone lesions allowed the diagnosis of botriomycoma on an underlying tuberculosis osteitis. Following surgical management associated with anti-tuberculosis treatment, the outcome was favorable. Botriomycoma is a well-known but little reported entity in the literature. It is a benign tumor that often reveals an underlying infectious but rarely bone site. Our case is the first in which this tumor allows us to discover tuberculosis osteitis of the tibia.