Objective: In this study our main goal is to evaluate the clinical and laboratory profile of patients with ovarian tumor. Method: This cross-sectional observational study was done at different tertiary hospitals from 2018 to 2020. Total 100 post-menopausal women with ovarian cysts aged 50-65 years were enrolled for this study. In each case, information about the patient was collected in a prescribed questionnaire after getting written consent from the patients in a preformed consent form. Results: During the study, (50%) of the patients belong to 54-57 years age group. 18% had family history of cancer, followed by 33.3% were nulliparas, 20.4% used barrier contraceptive method. According to histopathology report of the patients 27.9% cases mucinous cyst abdenomia were found followed by 18.7% cases endometrioma, in 17.5% cases serous cyst adenoma, 5.1% cases mucinous adenocarcinomas 5.6% cases papillary adenocarcinoma, 2.5% cases paraovarian cysts and benign cystic lesion and area of hemorrhagic infract were reported. Rt. Ovarian cyst about (10x6.6)cm cases were found 23.2% cases, followed by Rt. Adenexal mass about (12x9)cm found in 21.1% cases,11.6% cases Large complex mass about (13.9X12.8)cm were found, 6.3% cases cystic mass about (13x10)cm in the Lt. abdenexa were found, 5.3% cases Malignant ovarian tumor and complex pelvic mass about (9.3X7)cm were found. 26.6% cases mucinous cyst abdenomia were found followed by 17.7% cases endometrioma, in 16.5% cases serous cyst adenoma, 5.1% cases Mucinous adenocarcinoma and Papillary adenocarcinoma, 2.5% cases Peravarian cyst and Benign cystic lesion and area of hemorrhagic infract were reported. 32.4% cases were benign tumor and 16.2% cases were malignant.