Many studies have proven an inverse correlation between HDL rate and the risk of evolving toward an ischemic heart disease. This study’s goal is to spot patients with significantly low HDL to attempt finding new eventual elements characterizing this kind of situation, or at least, affirm the stability of those already acquired. It is a transversal study conducted in the biochemistry and toxicology department at the moulay Ismail Military hospital in Meknes over a one year period (June 2014 – June 2015). The retained patients were ones with an HDL lower than 0.20 g/l. Their medical files were taken from the appropriate services to collect on a record operating the interesting data for the study. 50 patients were taken in. Their average age was 51, 7 year old and the sex ration M/W was 1.4. The infections disease followed half of the cases, malaria being the majority with 32% of cases infections. 28% of cases were patients with cancer, 10% patients with diabetes. 6% were psychiatric diseases and 6% were malnutrition associated with inflammation cases. Hypertriglyceridemia was associated to hypoHDLemia in 46% of cases. HypoHDLemia can be transitory with acute infections and disappear along with it. Nevertheless, it can persist with chronical infections such as viral hepatitis, cancer, diabetes and psychiatric diseases, hence the value of a regular control of the lipid profile.