The scenario of the COVID-19 pandemic and the existing care conditions are different in each country. The risk factors for contamination can directly affect health professionals, especially nursing professionals, causing a worsening of the pandemic at the time of their illness and death. To identify risk factors for COVID-19 infection in nursing professionals in the care of suspected or confirmed COVID-19 patients. A protocol for a Systematic Review and Meta-Analysis study has been developed, supported by the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P), and registered in the International Prospective Register of Systematic Reviews (PROSPERO) under number CRD42020178168. The research question was structured according to the PICO strategy, P – nursing professionals; I – any nursing care to suspected or confirmed COVID-19 patient; C – nursing professionals without COVID-19 infection; O – nursing professionals with confirmed COVID-19 infection. Defined as follows: What are the risk factors associated with COVID-19 infection in nursing professionals with suspected or confirmed COVID-19 infection? In order to better plan the use of electronic searches, the following databases were consulted given the specificities of each database, specific search strategies were chosen for each database. Once the inclusion and exclusion criteria have been applied, the quality of the evidence will be assessed by applying the Grading of Recommendations, Assessment, Development and Evaluation.T. Ethics and disclosure: review study with primary articles already published. Therefore, it does not require authorization from any Ethics Committee. Trial registration number: CRD42020178168 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020178168