Objectives: This study assessed the prevalence of complementary/alternative medicine (CAM) use among dental patients in Riyadh. Methods: This cross-sectional study surveyed dental patients attending King Saud University Dental Hospital in Riyadh, KSA. The questionnaire included a consent form, questions on demographics, patients’ medical status, CAM types used for medical and/or dental conditions, patients’ assessment of their effects, and patients’ opinion on CAM as a choice of treatment. Use of CAM was compared by gender and by health status. Results: There were 373 respondents. More than one-third had tried CAM, with a significant difference between the genders (P < 0.001), whereas 43.1% reported use of CAM by their friends and relatives. Statistical significance was found in individuals reporting poor health status with the use of both herbs and wet-cupping (Hejama) (P < 0.05). Use of CAM for dental/oral conditions was reported by 31.2%, mainly for dental pain. Use of CAM for oral conditions by males approached statistical significance (P = 0.056). Most (83.8%) agreed with the suggestion of combining CAM with conventional medicine in hospital settings. Conclusions: Thus, more than one-third of patients attending a university dental clinic used CAM for various reasons and agreed with the suggestion of combining CAM with conventional medicine in hospital settings. It is essential to raise the public’s awareness of CAM.