Background: Psychiatric symptoms which constitute a major and growing public health problem of anxiety, depression, and cognitive dysfunction often occur in patients suffering from somatic conditions like asthma and chronic obstructive pulmonary disease (COPD). In Bangladesh, we have very little research-oriented information regarding these issues. Aim of the study: The aim of this study was to determine the association of anxiety and depression with asthma and COPD. Methods: This cross-sectional observational study was conducted at the Department of Respiratory Medicine in the National Institute of Diseases of the Chest and Hospital from March 2018 to February 2019. A total of 160 cases of Asthma and COPD were enrolled in this study as study. Statistical analyses of the results were obtained by using Windows-based computer software devised with Statistical Packages for Social Sciences (SPSS-23.0). Results: In this study in total 98 (61.3%) patients had COPD and 62 (38.7%) had asthma. Among 98 COPD patients 10 (10.2%) had mild, 29 (29.6%) had moderate, 40 (40.8%) had severe and 19 (19.4%) had very severe COPD. Among 62 asthmatic patients 22 (35.5%) had mild, 16 (25.8%) had moderate, 11 (17.7%) had severe and 13 (21.0%) had very severe asthma. Among total participants, the mean Beck depression inventory score was found 95.6±12.6, the mean anxiety rating scale score was found 61.0±11.7 and the mean HADS score was found 12.1±1.5. In COPD patients, the mean Beck depression inventory score was found at 99.9±10.7, the mean anxiety rating scale score was found 57.1±10.7 and the mean HADS score was found 11.8±1.3. On the other hand, in asthmatic patients, the mean Beck depression inventory score was found 88.8±12.4, the mean anxiety rating scale score was found 67.4±10.3 and the mean HADS score was found 12.6±1.7. Conclusion: We can conclude that the Beck depression inventory score, anxiety rating scale score, and HADS score were statistically significant when compared to the level of severity of COPD and asthma. Excluding other risk factors for anxiety and depression, still, COPD & asthma patients remain at risk of both anxiety and depression.