In fact, there are many different factors affect the development of highly qualified human resources in Nam Dinh province, including both micro and macro factors that have an influence. With the research approach to state management in human resource development, the influencing factors considered are macro factors. In this content, the authors study the macro factors affecting the province’s highly qualified human resources development, including: State management of central high qualified human resources development; Education-training factor; Economic factors; Labor force; Science and technology; Socio-culture... to build a linear regression function to determine the degree of influence of quantitative factors on the development of highly qualified human resources of Nam Dinh province.