Primary Squamous cell carcinoma of the gallbladder is extremely rare and constitutes 0.5- 3% of all gall bladder malignancies. We report a 50-year-old female who presented with vague symptom of right upper quadrant pain. She was operated on a presumptive diagnosis of chronic cholecystitis according to clinical and ultrasonography findings. Histopathological examination showed an infiltrating mass of the gallbladder which revealed well differentiated keratinized squamous cell carcinoma invading full wall thickness. Thorough evaluation revealed no other primary site for the tumor. Pure primary squamous cell carcinoma of the gallbladder is very rarely reported. Clinicians must be aware of its vague clinical presentations.