Catheter associate Urinary tract infection (CAUTI) is common health care–associated infection and widely found in hospitals and long term care facilities. Recent studies reported urinary pathogens showing resistance to most commonly prescribed antibiotics. Area specific study to find out the pathogen responsible for CAUTI and their resistant pattern which will be helpful for clinician to choose proper treatment and strategies to prevent infection in future. The infection rate was 52% among 200 patients using indwelling catheter. It was anticipated when catheter was used for longer period infection rate up to 60%. E. coli was most frequent detected bacteria and amikacin found most effective among the antibiotic we tested. Overall hospital stay and financial burden of patients increased due to CAUTI compared to the patients without infection.