Cemento-osseous dysplasia is a non-neoplastic condition in which a normal bone architecture is replaced with cemento-osseous tissue. It is a benign fibro-osseous lesion of the jaws associated to root apexes and containing amorphous calcifications which would correspond to cementum. They are classified, according to their extent and radiological appearance, into three main groups: peri-apical, Florida and focal cementitious dysplasia. Moreover, two forms can be described for Florida cemento-osseous dysplasia (FCOD): symptomatic, which is the most frequent, and asymptomatic. The treatment differs according to the form. Indeed, in case of symptomatic lesions, surgical management can cause the loss of interrupting substance. It must be completed by a prosthetic rehabilitation that allows the patient to resume his mandibular functions, especially mastication. In our work and through a clinical case, we will highlight the steps of the prosthetic rehabilitation of a loss of non-interruptive mandibular substance following the removal of a bone sequester caused by cemento-osseous dysplasia.