The synthesis and characterization of two hetarylazo disperse colorants is described. These compounds were used for the preparation of ink-jet inks with and without active agents for digital printing. Viscosity, surface tension, conductivity and pH values of all inks, with and without active agent, were monitored over a period of 90 days and were related to the ink stability. The same properties were measured for an ink preparation with a commercial dye for comparison. The inks which containing the new synthesized compounds with and without active agent were applied by exhaustion (dyed) on polyester and polyamide samples. Fastness (light, wash and rub) and also color properties of the samples were measured. Also, quantitative determination of the new antimicrobial agent was made from the dyed samples with exhaustion. The optimum application level required to give long lasting antimicrobial protection was determined by carrying out a series of antimicrobial testing.