Background: Organophosphorus (OP) poisoning, in addition to its cholinergic manifestations shows metabolic derangements leading to hyperglycaemia. The present study aims to assess the glycaemic status of OP poisoned patients and its association with severity and clinical outcome. Random blood sugar (RBS) level is an important factor influencing the severity of organophosphorus (OP) compound poisoning. RBS and its association with POP Scale can be used as a prognostic and mortality indicator in OP compound poisoning. Objectives of the study: 1. To estimate Serum Pseudocholinesterase and Random blood glucose levels in Acute OP Poisoning. 2. To correlate with the clinical criteria described by the POP scale at initial presentation and the severity of poisoning. Methods: This is a prospective study done on 90 patients above 18 years of age admitted to hospitals attached to Bangalore Medical College and Research Institute with history of Acute OP poisoning from November 2018 to May 2020. They were categorized into 3 grades-mild, moderate and severe based on the Peradeniya Organophosphorus Poisoning Scale. The routine biochemical parameters along with serum cholinesterase and Random blood glucose level were estimated in the study group. Results: Hyperglycaemia (RBS>200) was observed in 18(20%) of patients. Mean age group of patients was 32.68. Out of 90 subjects, 18 subjects had RBS levels above 200 and 72 subjects had RBS levels less than 200. Out of 18 subjects, 7 had mild POP scale, 8 had moderate POP scale and 3 had severe POP scale. Out of 18(100%) subjects having RBS scores of above 200, there were 7(38.9%) mortality noted (2-mild, 2-modertae and 3 severe POP scale). Out of 72(100%) subjects having RBS scores less than 200, there were 2(2.8%) mortality noted (1-modertae and 1 severe POP scale).Chi- square test showed significant association between POP scale and mortality in group having above 200 RBS levels(p<0.05). Conclusions: Glycemic status and POP Scale at the time of presentation in OP poisoning may play a role in predicting the need for ICU, Ventilator and Mortality in peripheral health centres in developing countries.