This study was design to examine the Acute Dermal Toxicity, cumulative irritancy, Sub-Chronic Toxicity Test, delayed Toxicity Assessments and Microbial Quality Analysis of an Herbal drug for analgesic property as well as the phyto screening potential of the product. Six samples of the product were submitted to the Department of Pharmacology and others for the analysis at the Kwame Nkrumah University of Science and Technology, KNUST, Kumasi, Ghana, as part of the Food and Drug Authority (FDA) herbal drug registration protocol. The result proved that, the herbal product formulated for pain relief is safe to use in experimental animals and therefore could be safe to use as a topical application.